Search results for " scandium"
showing 5 items of 5 documents
Gallium-68 and scandium-44 labelled radiotracers based on curcumin structure linked to bifunctional chelators: Synthesis and characterization of pote…
2019
Abstract Curcumin metal complexes showed widespread applications in medicine and can be exploited as a lead structure for developing new tracers for nuclear medicine application. Herein, the synthesis, chemical characterization and radiolabelling with gallium-68 and scandium-44 of two new targeting vectors based on curcumin scaffolds and linked to the chelators 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid (NODAGA) and 1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine (AAZTA) are reported. Synthesis of the precursors could be achieved with a 13% and 11% yield and radiolabelling generally afforded rapid incorporation under mild conditions (>95%). Sta…
Growth and Characterization of Anodic Films on Scandium
2013
The anodic behavior of Sc in a slightly alkaline aqueous solution is studied. Electrochemical and capacitance measurements suggest that passive films can be formed on the scandium surface under a high electric field. The formation of these layers occurs at low faradaic efficiency due to oxygen evolution. Photoelectrochemical experiments suggest the formation of a barrier layer with a thickness high enough to hinder external electron photoemission processes and allow the estimation of the bandgap of the films as a function of their formation voltage. The estimated bandgap values were lower than that reported for Sc2O3, suggesting the formation of hydrated phases and/or of a strongly oxygen d…
In Vitro Evaluation of the Squaramide-Conjugated Fibroblast Activation Protein Inhibitor-Based Agents AAZTA5.SA.FAPi and DOTA.SA.FAPi
2021
Recently, the first squaramide-(SA) containing FAP inhibitor-derived radiotracers were introduced. DATA5m.SA.FAPi and DOTA.SA.FAPi with their non-radioactive complexes showed high affinity and selectivity for FAP. After a successful preclinical study with [68Ga]Ga-DOTA.SA.FAPi, the first patient studies were realized for both compounds. Here, we present a new squaramide-containing compound targeting FAP, based on the AAZTA5 chelator 1,4-bis-(carboxylmethyl)-6-[bis-(carboxymethyl)-amino-6-pentanoic-acid]-perhydro-1,4-diazepine. For this molecule (AAZTA5.SA.FAPi), complexation with radionuclides such as gallium-68, scandium-44, and lutetium-177 was investigated, and the in vitro properties of…
Isomorphous ion substitutions and order-disorder phenomena in highly electrocaloric lead-scandium tantalate solid solutions
1996
Abstract The authors discuss the physical background of the electrocaloric effect in PST ceramics and its solid solutions. The most important contribution to the electrocaloric effect is due to field-induced Fm3m→R3m phase transition in the case of high long range ordering degree of B-ions in the perovskite structure ABO3.
On lead-scandium tantalate solid solutions with high electrocaloric effect
1992
Abstract The PbSc0,5Ta0,5O3 solutions are found to be a useful material for active elements of microcryogenic devices based on electrocaloric effect. A temperature difference of ΔT = 1. 0-1.8 K at field intensities 20–30 kV/cm in the interval of 210–310 K can be achieved by simultaneous or separate introducing of Sb and Co ions in B-sites of the lattice. The most important contribution to the electrocaloric effect is due to field-induced Fn3m → R3m phase transition in the case of high ordering of B-ions in the perovskite structure ABO3.